Disruption of the Estrogen Receptor Gene in Mice†
نویسندگان
چکیده
منابع مشابه
Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.
The reproductive system of male mice homozygous for a mutation in the estrogen receptor (ER) gene (ER knock-out; ERKO) appears normal at the anatomical level. However, these males are infertile, indicating an essential role for ER-mediated processes in the regulation of male reproduction. Adult ERKO male mice have significantly fewer epididymal sperm than heterozygous or wild-type males. Althou...
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Here we provide the first evidence, to our knowledge, that estradiol (E2) affects learning and memory via the newly discovered estrogen receptor (ER ). In this study, ER knockout (ER KO) and wild-type littermates were tested for spatial learning in the Morris water maze after ovariectomy, appropriate control treatment, or one of two physiological doses of E2. Regardless of treatment, all wild-t...
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The role of the a form of estrogen receptor (ERa) gene expression in the regulation of testosterone-dependent male reproductive behaviors was investigated using ER knockout mice (ERKO), which are specifically deficient in functional ERa, but not ERb, gene expression. Previous studies in gonadally intact ERKO mice revealed that male aggressive behavior was greatly reduced by the lack of a functi...
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The role of the a form of estrogen receptor (ER alpha) gene expression in the regulation of testosterone-dependent male reproductive behaviors was investigated using ER knockout mice (ERKO), which are specifically deficient in functional ER alpha, but not ER beta, gene expression. Previous studies in gonadally intact ERKO mice revealed that male aggressive behavior was greatly reduced by the la...
متن کاملTargeted Disruption of the Estrogen Receptor-α Gene in Female Mice: Characterization of Ovarian Responses and Phenotype in the Adult.
Targeted disruption of the mouse estrogen receptor-alpha gene (estrogen receptor-alpha knockout; ERKO) results in a highly novel ovarian phenotype in the adult. The ERKO mouse model was used to characterize ER alpha-dependent processes in the ovary. Visualization of the ovaries of 10-, 20-, and 50-day-old wild-type (WT) and ERKO mice showed that the ERKO phenotype developed between 20 and 50 da...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1997
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339702500516